Mechanisms of Arrhythmias genetic basis Ion channel or Chromosome type involved Defective gene proteins result affected LQT1 11 KCNQ1 Loss of function LQT2 7 HERG Loss of function LQT3 3 SCN5A a Gain of function LAQT4 4 Ankyrin-B Loss of function LQT5 21 KCNE1(mink) Loss of function LQT6 21 KCNE2 Ikr Loss of function LQT7 KCNJ2 Loss of function Brugada 3 SCN5A Loss of function syndrome Familial atrial 11 KCNQ1 Gain of function fibrillationMechanisms of Arrhythmias – genetic basis type Chromosome involved Defective gene Ion channel or proteins affected result LQT1 11 KCNQ1 IKs Loss of function LQT2 7 HERG IKr Loss of function LQT3 3 SCN5A INa Gain of function LAQT4 4 Ankyrin-B Loss of function LQT5 21 KCNE1(mink) IKs Loss of function LQT6 21 KCNE2 IKr Loss of function LQT7 KCNJ2 Loss of function Brugada syndrome 3 SCN5A INa Loss of function Familial atrial fibrillation 11 KCNQ1 IKs Gain of function