Natural Products as Tools for Neuroscience Natural Products as Modulators of Bio-molecular Function Natural Products as modulators of Natural Pro Bio-molecular Function 灯 人 是 X属于新型的纳罐道功有是引复人类中毒分布广的一种毒素26万人年 Natural Products as Pharmacologic Tools Natural Produets as Chemical Probes to Study Signaling Pathway 帕等素可以让我们活过00岁 8 1率在南上有。年在中国上市 影d2m:水6365 3 N NH O O OCH3 O OCH3 OCH3 OCH3 H3CO OCH3 H O H H O O O O OH OH OH OH H N H3C O OH OH H Morphine Δ9-tetrahydrocannabinol Forskolin Reserpine Natural Products as Tools for Neuroscience Natural Products as Tools for Neuroscience 毛喉素：腺苷酸环化酶激活剂 Natural Products as Modulators of Natural Products as Modulators of Bio-molecular Function N H N O O OH H NH HO OH HO OH H OH + 1 4 4a 8 10 11 6 Tetrodotoxin has been used extensively as a tool in the study of sodium channel pharmacology. O O O O O O O HO O OH OH HO OH 大田软海绵酸(Okadaic Acid) 是一种肿瘤促进剂，能抑制由钙激活 的磷脂依赖的蛋白激酶，是一种特殊的蛋白质磷酸酯酶1、2A和2B的抑 制剂，作为研究细胞调控的工具药。 Natural Products as Modulators of Natural Products as Modulators of Bio-molecular Function O O HO O HO 从海绵中分离的Manoalide是第一 个具有选择性作用于磷酯酶A2 （PLA2），现已成为研究阻断 PLA2的常规工具药。 Eleutherobin 从软珊瑚中分离的 二萜苷，具有紫杉烷一样的抗癌机 制，对乳腺、肾、卵巢及肺癌细胞有 极高的选择性，是未来几年有希望发 展为抗癌剂的候选化合物。 O O O N N O O OH OH OAc OMe 西加毒素(Ciguatoxin, CTX)是电压依赖性Na+通道激动剂，可作为 研究兴奋细胞膜结构与功能以及局麻药作用机理的分子探针。 O O O O O O O O O O O O O H H H H H HO H H H H OH H OH H H H H H H H H H H OH HO OH CTX 属于新型的钠通道激动剂,是引起人类中毒分布最广的一种毒素2-6万人/年 Natural Products as Natural Products as Pharmacologic Tools Pharmacologic Tools to Explore to Explore Bio-molecular Function Brefeldin A is a fungal metabolite used as a biological research tool for studying protein transport. Natural Products as Natural Products as Pharmacologic Tools Pharmacologic Tools to Study Signaling Pathway to Study Signaling Pathway Trapoxin A是组蛋白去乙酰化 酶(histone deacetylases)抑制剂 Trapoxin cause cell cycle arrest in mammalian cells and inhibit histone deacetylation. N S O O OH O OH O Epothilone B Epothilone B has similar modes of action to Taxol and is derived from the fermentation of Sorangium cellulosum. O H OH HO H O Brefeldin A NH N HN HN O O O O O O Trapoxin A Natural Products as Chemical Probes Natural Products as Chemical Probes Rapamycin and its derivatives have played important roles in the clarification of several cellular processes including cell growth, proliferation, and survival as well as protein synthesis and transcription. O O OH O N O O O H OMe O HO H MeO MeO HO ACS Chem Biol. 2010; 5(7): 639-653. 雷帕霉素靶点 mTOR信号途径 雷帕霉素可以让我们活过100岁？ 1999年在美国和欧洲上市，2003年底在中国上市 Dr. Suren N. Sehgal