安微医科大学国际教育学院教案与讲稿 Title of the course: Time Course of Drug Response Chapter: 19 Teacher's name: Dr.Qingtong Wang Grade:2013 Department:School of International Education Time:14:30-16:50 Date (D/M/Y): 3/23/2016 Lecture Notes: [INTRODUCTION] 2min Drug dose--Drug concentration--Drug exposure Immediate Drug Effects Delayed Drug Effects Cumulative Drug Effects [IMMEDIATE DRUG EFFECTSI 2min Drug Action Potentiation of GABA receptor activation Drug Effect Slowing of EEG activity Drug Response Anesthesia Response in Minutes EXAMPLESI 6min Thiopentone time course [DELAYED DRUG EFFECTSI 3min Drug Action:inhibition of Vit K recycling Drug Effect:decreased synthesis of clotting factors Drug Response:prolonged coagulation time [PHYSIOKINETIC DELAYED RESPONSE 4min Angiotension Converting Enzyme Inhibitors(enalapril) Delayed effect on blood pressure(1 week) Half-life of Na+is about 2 days Anti-Depressants(amitriptyline) Delayed effect on depression(2 weeks) Unidentified mediator A protein with a 4 day half-life? [CUMULATIVE DRUG RESPONSE] 2min Action:inhibition of gastric acid pump Effect:decreased acid secretion and increased pH Response:ulcer healing 2安徽医科大学国际教育学院教案与讲稿 2 Title of the course: Time Course of Drug Response Chapter: 19 Teacher’s name: Dr. Qingtong Wang Grade: 2013 Department: School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/23/2016 Lecture Notes: [INTRODUCTION] 2min Drug dose--Drug concentration--Drug exposure Immediate Drug Effects Delayed Drug Effects Cumulative Drug Effects [IMMEDIATE DRUG EFFECTS] 2min Drug Action Potentiation of GABA receptor activation Drug Effect Slowing of EEG activity Drug Response Anesthesia Response in Minutes [EXAMPLES] 6min Thiopentone time course [DELAYED DRUG EFFECTS] 3min Drug Action: inhibition of Vit K recycling Drug Effect: decreased synthesis of clotting factors Drug Response: prolonged coagulation time [PHYSIOKINETIC DELAYED RESPONSE] 4min Angiotension Converting Enzyme Inhibitors (enalapril) Delayed effect on blood pressure (1 week) Half-life of Na+ is about 2 days Anti-Depressants (amitriptyline) Delayed effect on depression (2 weeks) Unidentified mediator A protein with a 4 day half-life? [CUMULATIVE DRUG RESPONSE] 2min Action: inhibition of gastric acid pump Effect: decreased acid secretion and increased pH Response: ulcer healing