安徽医科大学国际教育学院教案与讲稿 ICUMULATIVE DRUG RESPONSEI lmin Takes several weeks of acid inhibition to heal an ulcer Acid inhibition effect is constant but the Response continues to develop(e.g.smaller size of ulcer) Response time course is(almost)independent of drug dose/concentration when inhibition is nearly 100% [CUMULATIVE DRUG RESPONSE] 2min Diuretics are used to treat heart failure with digoxin and ACE inhibitors Symptoms are produced by excess fluid Ascites,edema,breathlessness,ankle swelling,(dropsy) Benefit is related to reduction in fluid [CUMULATIVE DRUG RESPONSE 3min Action Inhibition of Na*reabsorption Effect Increased Na+and H20 excretion Cumulative fluid loss Response Reduced ankle swelling Decreased breathlessness [CMULATIVE DRUG EFFECTS] 2min Response is NOT proportional to cumulative diuretic dose or AUC Response IS proportional to cumulative diuretic effect or AUCe Phenomenon is known as Schedule Dependence" [CUMULATIVE DRUG RESPONSE] 3min Anti-Cancer Agents Schedule Dependence is ·Action common -Irreversible binding to cell structure Large intermittent doses are often more toxic and less Effect effective than smaller repeated doses Block of cell division/cell death Slowing or reversal of Response is related to tumour growth cumulative dose as well as schedule Response AUC may be used to guide -Decreased morbidity (e.g. Pain) individual treatment Postponement of death 3安徽医科大学国际教育学院教案与讲稿 3 [CUMULATIVE DRUG RESPONSE] 1min Takes several weeks of acid inhibition to heal an ulcer Acid inhibition effect is constant but the Response continues to develop (e.g. smaller size of ulcer) Response time course is (almost) independent of drug dose/concentration when inhibition is nearly 100% [CUMULATIVE DRUG RESPONSE] 2min Diuretics are used to treat heart failure with digoxin and ACE inhibitors Symptoms are produced by excess fluid Ascites, edema, breathlessness, ankle swelling, (dropsy) Benefit is related to reduction in fluid [CUMULATIVE DRUG RESPONSE] 3min Action Inhibition of Na+ reabsorption Effect Increased Na+ and H2O excretion Cumulative fluid loss Response Reduced ankle swelling Decreased breathlessness [CMULATIVE DRUG EFFECTS] 2min Response is NOT proportional to cumulative diuretic dose or AUC Response IS proportional to cumulative diuretic effect or AUCe Phenomenon is known as Schedule Dependence” [CUMULATIVE DRUG RESPONSE] 3min Anti-Cancer Agents