中 (f) FROM THE CHARLIER MMODEL 中1A t kt t Cmo kt Dot p 9.00E+00 8.00E+00 7.00E+00 5.00E+00 E4.00E+00 Charlier MW-D relationship 3.0oE+0 0.00E+00 3.(10 pts)Using the data above and that given below, determine how long release experiments that measure Q(t)(total amount of drug released at time t)would need to be carried out to distinguish which of the two models for the diffusion constant (D=Doe as derived in class, or the expression given above) best represents release of HGH from a PLGa matrix in the framework of the charlier model. Hint: plot Q(t) for each of the two models; solve for Q(t) in model b by numerically integrating an expression dQ (-)dt Solubility of HGH in PLGA matrix Concentration of HGH encapsulated in the matrix: Co=0.02 g/cm Surface area of release matrix Initial molecular weight of the matrix Mo=78,000 g/mole BE.462 PS 3 3 of 4BE.462 PS 3 3 of 4 0.00E+00 1.00E+00 2.00E+00 3.00E+00 4.00E+00 5.00E+00 6.00E+00 7.00E+00 8.00E+00 9.00E+00 0 2 4 6 8 10 time (hr) h (µm) Faisant MW-D relationship Charlier MW-D relationship 3. measure Q(t) t) would need to be carried out to distinguish which of the two models for the diffusion constant (D = D0ekt as derived in class, or the expression given above) best represents release of HGH from a PLGA matrix in the framework of the Charlier model. (Hint: plot Q(t) for each of the two models; solve for Q(t) in model B by numerically integrating an expression dQ = (…)dt.) Solubility of HGH in PLGA matrix: Cs = 6.12E-04 g/cm3 Concentration of HGH encapsulated in the matrix: C0 = 0.02 g/cm3 Surface area of release matrix: A = 1.67 cm2 Initial molecular weight of the matrix: M0 = 78,000 g/mole (10 pts) Using the data above and that given below, determine how long release experiments that (total amount of drug released at time