AGAIN USING THE CHARLIER WOD:L ⊥d:DC RIi. Gi A Φ ≌(Dt;中( P。k sivcs G)is Nur STRNIGN FoRwArD To IATLGRATE, WL CAN OBTAIN A REASOMAe UoMctICAL ESTIMAT. Fok QLt) USING ()INSTLAD dQ A Du)Cc (v) AQ: Ab(t)Cs At, WRE AP: IS THE AMOUNT OF DRUG RCLEASD IN A SMALL TiME INTERVAL Q\s OBTAINED 8f SUMMING Au Tit 4<: FRoM TiME 1t) SINCE WE HAv. ExFuCIT EXPR<SSONS FoR D()AND hct),(iv)AND (v) A、PM有所AD/的An/CAe NUMRICAL CE7Au(t)W的LB Using the derived expressions, we can compare release predicted by model a and mode/ B 3.00E-02 2.50E-02 Charlier MW-D 2.00E-02 relationsh Charlier MW-D 1.00E-02 relationship, discrete 5.00E-03 0.00E+00 Thus, for the given parameters, release experiments carried out for at least 2 days would be necessary for the 2 models to deviate from one another significantly. Release experiments carried out for 10 days should allow an unequivocal determination of which model better fits the experimental system BE.462 PS 3BE.462 PS 3 4 of 4 Using the derived expressions, we can compare release predicted by model A and model B: 0.00E+00 5.00E-03 1.00E-02 1.50E-02 2.00E-02 2.50E-02 3.00E-02 0 2 4 6 8 10 time (days) Q (mg drug released) Charlier MW-D relationship Faisant MW-D relationship Charlier MW-D relationship, discrete integral Thus, for the given parameters, release experiments carried out for at least 2 days would be necessary for the 2 models to deviate from one another significantly. should allow an unequivocal determination of which model better fits the experimental system. Release experiments carried out for 10 days