Antigenic properties of antibodies Isotypic determinant of C regions. eround in mof thesme Allotypic determinant of C region.Found in Thus,individuals may po determinant.Antibodies can be obtrained ich does ceratin diseases. otypic determinants of v regions. irdg9r8oe8nt1geneemiCautego generated by the hypervariable subregions CDRs)on the santigens.There are three tugus to e ca diotopes Physical and Biological characteristic of Human Immunoglobulin Characteristic mmunogl obul in Isotypes IgA IgD IgE IgG IgM Chemical and physical traits cular Weight (KD) 385 160-184160-200150-170146-970 Sedimentation Coefficient(S) 7-9 8 7 719 Electrophoretic Mobility B-Y y B-Y y Carbohydrate content() 7-119-1412 2-312 Heavy chain class 8 Light chain class x) Biological Characteristics Serum Conc.(mg/dl) 50-4001.5-400.005800-1,600 50-200 Half-life (day) 6 3 2 21Physical and Biological characteristic of Human Immunoglobulin _____________________________________________________________________________ Characteristic Immunoglobulin Isotypes IgA IgD IgE IgG IgM _____________________________________________________________________________ Chemical and physical traits Molecular Weight (KD) 385 160-184 160-200 150-170146-970 Sedimentation Coefficient (S) 7-9 7 8 7 7-19 Electrophoretic Mobility -  −   Carbohydrate content (%) 7-11 9-14 12 2-3 12 Heavy Chain Class      Light chain Class           _____________________________________________________________________________ Biological Characteristics Serum Conc. (mg/dl) 50-4001.5-400.005800-1,600 50-200 Half-life (day) 6 3 2 21 5