4.教学方法 (1)Teaching method:Relevant concepts and theoretical framework,combined with typical drug examples. (2)Discussion method:Flipped classroom was encouraged. 5.教学评价 Take quick summary test,discuss with selected learning questions and frequently asked questions. 第四章Multicompartment Models:Intravenous Bolus Administration 1.教学目标 (1)Define the pharmacokineticterms used in a two-and threecompartment model. (2)Explain using examples whydrugs follow one-compartment,two-compartment,or threecompartment kinetics. (3)Use equations and graphto simulate plasma drugconcentration at varioustime periods after an IV bolusinjection of a drug that followsthe pharmacokinetics of a twoand three-compartment modeldrug. (4)Estimate two-compartmentmodel parameters by using themethod of residuals. 2.教学重难点 Whydrugs follow one-compartment,two-compartment,or threecompartment kinetics,estimate two- compartmentmodel parameters by using themethod of residuals. 3.教学内容 Two-Compartment Open Model,Clinical Application,Three-Compartment Open Model,Determination of Compartment Models,Practical Problem 4.教学方法 (1)Teaching method:Relevant concepts and theoretical framework,combined with typical drug examples.4.教学方法 (1) Teaching method: Relevant concepts and theoretical framework, combined with typical drug examples. (2) Discussion method: Flipped classroom was encouraged. 5.教学评价 Take quick summary test, discuss with selected learning questions an d frequently asked questions. 第四章 Multicompartment Models: Intravenous Bolus Administration 1.教学目标 (1) Define the pharmacokineticterms used in a two- and threecompartment model. (2) Explain using examples whydrugs follow one-compartment,two-compartment, or threecompartment kinetics. (3) Use equations and graphto simulate plasma drugconcentration at varioustime periods after an IV bolusinjection of a drug that followsthe pharmacokinetics of a twoand three-compartment modeldrug. (4) Estimate two-compartmentmodel parameters by using themethod of residuals. 2.教学重难点 Whydrugs follow one-compartment,two-compartment, or threecompartment kinetics, estimate two￾compartmentmodel parameters by using themethod of residuals. 3.教学内容 Two-Compartment Open Model, Clinical Application, Three-Compartment Open Model, Determination of Compartment Models, Practical Problem 4.教学方法 (1) Teaching method: Relevant concepts and theoretical framework, combined with typical drug examples