CHRONIC INFLAMMATION in COPD Large Small Alveolar airway alrway space Mucous Excess mucous ECM gland edema destruction enlargement Fibrosis Emphysema Goblet cell Destruction of elastic hy perplasia fibers Impaired Small airway narrowing collapse muco-CIllary clearance Airflow Air Hyper obstruction trapping inflation Cough Sputum Progressive DyspneaLarge airway Mucous gland enlargement Goblet cell hyperplasia Impaired muco-ciliary clearance Cough Sputum Small airway Excess mucous & edema Fibrosis Destruction of elastic fibers CHRONIC INFLAMMATION in COPD Small airway narrowing & collapse Airflow obstruction Air trapping Hyper￾inflation Alveolar space ECM destruction Emphysema Progressive Dyspnea