o Primary biliary cirrhosis(PBC) is a chronic cholestatic liver disease involving the interlobular and septal bile ducts. This disorder is characterized by progressive inflammatory destruction of these bile ducts with the development of portal and periportal inflammation. subsequent fibrosis, and eventually cirrhosis. Portal hypertension and the consequences of end-stage liver disease can lead to early death unless effective therapy or liver transplantation intervenes⚫ Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease involving the interlobular and septal bile ducts. This disorder is characterized by progressive inflammatory destruction of these bile ducts with the development of portal and periportal inflammation, subsequent fibrosis, and eventually cirrhosis. Portal hypertension and the consequences of end-stage liver disease can lead to early death unless effective therapy or liver transplantation intervenes