N C OH O O OH - C N Br CN + CNBr REARRANGEMENT RING IS OPENED REARRANGED DERIVATIVE S O O H2N O H RERRANGED DERIVATIVE + O H O O R-N-CH=CH-CH=C-CH=N S C-OH O 1 2 Niacine DeterminationN C OH O O OH - C N Br CN + CNBr REARRANGEMENT RING IS OPENED REARRANGED DERIVATIVE S O O H2N O H RERRANGED DERIVATIVE + O H O O R-N-CH=CH-CH=C-CH=N S C-OH O 1 2 Niacine Determination