d)within the pseudo-autosomal regions of the Y and X chromosomes during mitosis in males. e)within the telomeres of X and Y chromosomes during meiosis in females 5. Which of the following diseases has not been proposed to be caused by mutations under positive selection due to"heterozygote advantage"for resistance to an infectious disease? a)sickle-cell anemia b)thalassemia c)cystic fibrosis d)neurofibromatosis e)glucose-6-phosphate dehydrogenase deficiency 6. Which of the following is a false statement? a)Nonsense-mediated decay protects cells from the accumulation of mutant proteins b) Incorrectly spliced mRNAs are often eliminated via the nonsense-mediated decay pathway c)Indels within the 3-untranslated region (3-UTR) are likely to trigger mRNA degradation nonsense-mediated de d) Coding region Indels comprising numbers of nucleotides that are not evenly divided b 3 are likely to trigger mrna degradation via nonsense-mediated decay e) Non-sense mediated decay of mRNA encoding rate-limiting enzymes is often the mechanism underlying diseases caused by haploinsufficiency 7. Which of the following genetic diseases in not caused by expansion of a triplet repeat? a)Huntington's disease b)Alzheimers disease c)Fragile X disease d) Myotonic dystrophy e)Friedreich ataxia 8. hich of the following statements is false a)Relative risk for family members is defined as ratio of i)the prevalence of a disease among family members who share the same percentage of DNA with a proband to ii) the prevalence of the disease in the general population b)The relative risk for developing schizophrenia among relatives decreases with decreasing percentage of shared DNA with a proband with schizophrenia. c)Shared environments among relatives is a confounding factor in analyses aimed at quantify ing genetic contributions o this disorder d) The relative liability of developing schizophrenia can be modeled as a quantitative trait that is normally distributed in the population and among sets of family members who share the same degree of relatedness to a proband with schizophrenia. e)The chance of a person developing schizophrenia depends only upon types of genes the person has inherited from his/her parentsd) within the pseudo-autosomal regions of the Y and X chromosomes during mitosis in males. e) within the telomeres of X and Y chromosomes during meiosis in females. 5. Which of the following diseases has not been proposed to be caused by mutations under positive selection due to “heterozygote advantage” for resistance to an infectious disease? a) sickle-cell anemia b) thalassemia c) cystic fibrosis d) neurofibromatosis e) glucose-6-phosphate dehydrogenase deficiency 6. Which of the following is a false statement? a) Nonsense-mediated decay protects cells from the accumulation of mutant proteins. b) Incorrectly spliced mRNAs are often eliminated via the nonsense-mediated decay pathway. c) Indels within the 3’-untranslated region (3’-UTR) are likely to trigger mRNA degradation via nonsense-mediated decay. d) Coding region Indels comprising numbers of nucleotides that are not evenly divided by 3 are likely to trigger mRNA degradation via nonsense-mediated decay. e) Non-sense mediated decay of mRNA encoding rate-limiting enzymes is often the mechanism underlying diseases caused by haploinsufficiency. 7. Which of the following genetic diseases in not caused by expansion of a triplet repeat? a) Huntington’s disease b) Alzheimer’s disease c) Fragile X disease d) Myotonic dystrophy e) Friedreich ataxia 8. Which of the following statements is false? a) Relative risk for family members is defined as ratio of: i) the prevalence of a disease among family members who share the same percentage of DNA with a proband to ii) the prevalence of the disease in the general population. b) The relative risk for developing schizophrenia among relatives decreases with decreasing percentage of shared DNA with a proband with schizophrenia. c) Shared environments among relatives is a confounding factor in analyses aimed at quantifying genetic contributions to this disorder. d) The relative liability of developing schizophrenia can be modeled as a quantitative trait that is normally distributed in the population and among sets of family members who share the same degree of relatedness to a proband with schizophrenia. e) The chance of a person developing schizophrenia depends only upon types of genes the person has inherited from his/her parents