a 1-2 Site-specific recombinases cleave and a rejoin DNA using a covalent protein-DNA 后 intermediate Serine Recombinases : Tyrosine Recombinases cleaved dNA end 5-070 ase cleavage H Rec. Ser-OH 0 ase Rec.Ser-0-P-o base er-OH Fiqure 11-5 protein-DNA covalent intermediate◼ Serine Recombinases ◼ Tyrosine Recombinases Conservative Site -Specific Recombination 1-2 Site-specific recombinases cleave and rejoin DNA using a covalent protein-DNA intermediate Figure 11-5