Initiation Promotion Conversion Progression Defects in Terminal Differentiation Defects in Growth Control Resistance to Cytotoxicity Defects in Programmed Cell Death DeaclaicEacrwon Selective D Genetic Clonal Genetic Genetic Genet Expansi Change Change Inhition NORMAL CELL INITIATED PRENEOPLASTIC MALIGNANT CLINICAL CANCER CELL LESION TUMOR CANCER METASTASIS RUS e Activation of Proto-Oncogenes Inactivation of Tumor Suppressor Genes o Inactivation of Antimetastasis Genes Cancer Susceptibility Genes11