Normal cel O) Normal cell line CarcinogenIc agent DNA damage (chemicals and cell mutation Initiation Primary tumour radiation, viruses Metastatic subclone Mutated cell Intravasation Activation of oncogenes by Promotion promoter agent Tumour cell embolus Interaction with Platelets lymphocytes Malignant tumour Progression Extravasation Metastatic tumour. And bIogenesIs12