国以生 国上人连 ④Local action ©Systemic action Rectal suppositories intended for local are most frequently Drugs inactivated by the pH or enzymatic activity used to relieve constipation or the pain,irritation, of the stomach or intestines itching and inflammation associated with hemorrhoids Drugs irritating to the stomach 疮 Drugs destroyed by the liver .Vaginal suppositories intended for local effects are Patients who are unable or unwilling to swallow employed mainly as contraceptives孕s药，antiseptics. medication. Patients with vomiting. 图生 国生 栓剂基质 Components of suppositories Requirement of bases ·Active Ingredients Solid at room temperature Solve or suspend in base Soft,melt,or dissolve at body temperature ·Suppositories base Physical and chemical stability ·Fatty base Acid value,Saponification value,lodine value ·Water soluble base ·High water number ·Additive 国坠生一 国生 ©Fatty Base ©Water soluble base ·Cocoa butter可可豆脂 Gelatin glycerin(gelatin:glycerin: ·Semi--synthetic fatty glyeerides半合成甘油酯 water=-20:70:l0) ·PEG ·Polysorbate6l聚山梨酯6l ·Polyoxyl40 stearate聚氧乙烯单硬脂酸酯 ·Poloxamer 88 Shanghai Jiao Tong University Local action • Rectal suppositories intended for local are most frequently used to relieve constipation便秘 or the pain, irritation, itching and inflammation associated with hemorrhoids痔 疮. • Vaginal suppositories intended for local effects are employed mainly as contraceptives避孕药, antiseptics. Shanghai Jiao Tong University Systemic action • Drugs inactivated by the pH or enzymatic activity of the stomach or intestines • Drugs irritating to the stomach • Drugs destroyed by the liver • Patients who are unable or unwilling to swallow medication. • Patients with vomiting. Shanghai Jiao Tong University Components of suppositories • Active Ingredients • Solve or suspend in base • Suppositories base • Fatty base • Water soluble base • Additive Shanghai Jiao Tong University 栓剂基质 Requirement of bases • Solid at room temperature • Soft, melt, or dissolve at body temperature • Physical and chemical stability • Acid value, Saponification value, Iodine value • High water number Shanghai Jiao Tong University Fatty Base • Cocoa butter可可豆脂 • Semi-synthetic fatty glycerides 半合成甘油酯 Shanghai Jiao Tong University Water soluble base • Gelatin glycerin (gelatin: glycerin: water=20:70:10 ) • PEG • Polysorbate 61 聚山梨酯61 • Polyoxyl 40 stearate 聚氧乙烯单硬脂酸酯 • Poloxamer