Extracorpuscular Hemolysis Immune .All require antigen-antibody reactions .o Types of reactions dependent on: oR Class of Antibody cR Number Spacing of antigenic sites on cell aVAilability of complement cR Environmental Temperature cR Functional status of reticuloendothelial system ☆ Manifestations iNTravascular hemolysis eXTravascular hemolysisExtracorpuscular Hemolysis Immune ❖ All require antigen-antibody reactions ❖ Types of reactions dependent on: Class of Antibody Number & Spacing of antigenic sites on cell Availability of complement Environmental Temperature Functional status of reticuloendothelial system ❖ Manifestations Intravascular hemolysis Extravascular hemolysis