Extracorpuscular Hemolysis Immune Antibodies combine with rbc.& either 1. Activate complement cascade, &/or 2. Opsonize rbc for immune system %o If 1, if all of complement cascade is fixed to red cell. intravascular cell ysIs occurs &o If 2, &/or if complement is only partially fixed, macrophages recognize Fc receptor of Ig &/or C3b of complement phagocytize rbc, causing extravascular rbc destructionExtracorpuscular Hemolysis Immune ❖ Antibodies combine with RBC, & either 1. Activate complement cascade, &/or 2. Opsonize RBC for immune system ❖ If 1, if all of complement cascade is fixed to red cell, intravascular cell lysis occurs ❖ If 2, &/or if complement is only partially fixed, macrophages recognize Fc receptor of Ig &/or C3b of complement & phagocytize RBC, causing extravascular RBC destruction