安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Dose-effect and concentration-effect analysis Chapter:_ 18 Teacher's name: Dr.Qingtong Wang Grade: 2013 Department:School of International Education Time:14:30-16:50 Date(D/M/Y):3/23/2016 1.Recognize the mechanism of drugs for exerting their pharmacological effects. Teaching 2.Master the dose-effect endpoints(Graded and Quantal),parameters Objectives; Teaching 3.Recognize the major sources relating dose to effect in vivo Requirements 4.Recognize the pharmacodynamic models 5.Master the use of therapeutic drug monitoring(TDM)to target concentration intervention 1.Drug-receptor interaction Teaching 2.Graded/quantal dose-effect relationship Content 3.Pharmacodynamic models 4.The function of TDM in clinical practice Teaching Teaching Focus:Drug-receptor interaction,Graded/quantal dose-effect Focus; relationship,pharmacodynamic models,and the use of TDM Difficult Problems:dose effect and concentration effect analysis,and the Difficult pharmacodynamic models Problems Solutions:Show representative figures to explain the dose-effect relationship and their Solutions and pharmacodynamic models,give examples to introduce the characteristic in detail. 1.Drug-receptor interaction 15min Time 2.Graded/quantal dose-effect relationship 15min Allotment 3.Pharmacodynamic models 20min 4.TDM 10min 1.The definition of dose-effect curve,efficacy,potency. Assignment 2.Use examples to elucidate pharmacodynamic models. 3.What is therapeutic drug monitoring,its purpose and how to TDM? 1.Principle of Clinical Pharmacology(Second Edition);ArthurJ.Atkinson Reference 2.Basic Clinical Pharmacology;Bertram G.Katzung Text 3.Oxford Textbook of Clinical Pharmacology and Drug Therapy;David Grahame-Smith,Jeffrey Aronson Memo 1安徽医科大学国际教育学院教案与讲稿 1 Teaching Plan for International Students, AHMU Title of the course: Dose-effect and concentration-effect analysis Chapter: 18 Teacher’s name: Dr. Qingtong Wang Grade: 2013 Department: School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/23/2016 Teaching Objectives; Teaching Requirements 1. Recognize the mechanism of drugs for exerting their pharmacological effects. 2. Master the dose-effect endpoints (Graded and Quantal), parameters 3. Recognize the major sources relating dose to effect in vivo 4. Recognize the pharmacodynamic models 5.Master the use of therapeutic drug monitoring (TDM) to target concentration intervention Teaching Content 1. Drug-receptor interaction 2. Graded/ quantal dose-effect relationship 3. Pharmacodynamic models 4. The function of TDM in clinical practice Teaching Focus; Difficult Problems and their Solutions Teaching Focus: Drug-receptor interaction, Graded/ quantal dose-effect relationship, pharmacodynamic models, and the use of TDM Difficult Problems: dose effect and concentration effect analysis, and the pharmacodynamic models Solutions: Show representative figures to explain the dose-effect relationship and pharmacodynamic models, give examples to introduce the characteristic in detail. Time Allotment 1. Drug-receptor interaction 15min 2. Graded/ quantal dose-effect relationship 15min 3. Pharmacodynamic models 20min 4. TDM 10min Assignment 1. The definition of dose-effect curve, efficacy, potency. 2. Use examples to elucidate pharmacodynamic models. 3. What is therapeutic drug monitoring, its purpose and how to TDM? Reference Text 1. Principle of Clinical Pharmacology (Second Edition); ArthurJ. Atkinson 2. Basic & Clinical Pharmacology; Bertram G. Katzung 3.Oxford Textbook of Clinical Pharmacology and Drug Therapy; David Grahame-Smith, Jeffrey Aronson Memo