安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Dose-effect and concentration-effect analysis Chapter: 18 Teacher's name: Dr.Qingtong Wang Grade:2013 Department:School of International Education Time:14:30-16:50 Date (D/M/Y): 3/23/2016 Lecture Notes: JINTRODUCTIONI 1 min The intensity and duration of a drug's effects are a function of the drug dose and drug concentration at the effect site [CLASSIFICATION OF DRUGACTION] 4min Receptor mediated Drug action Receptors Ligands (Drugs) Ligand-receptor interaction--effect Non-receptor mediated Drug action Physical property--effect Chemical property--effect DOSE-EFFECT ENDPOINTSI 5min Graded Continuous scale(dose--effect) Measured in a single biologic unit Relates dose to intensity of effect Quantal All-or-none pharmacologic effect Population studies Relates dose to frequency of effect DRUG-RECEPTOR INTERACTIONS] 5min Effect=Maximal effect[Drug] Ko+[Drug] (Kp=k2/k) [DOSE-EFFECT CURVE] 3min Show some representative dose-effect curve and explain,such as:graded dose-effect curve, lidocaine graded dose-effect,theophylline dose-effect,metformin dose-response. [DOSE-EFFECT PARAMETERS] 3min 2安徽医科大学国际教育学院教案与讲稿 2 Teaching Plan for International Students, AHMU Title of the course: Dose-effect and concentration-effect analysis Chapter: 18 Teacher’s name: Dr. Qingtong Wang Grade: 2013 Department: School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/23/2016 Lecture Notes: [INTRODUCTION] 1 min The intensity and duration of a drug’s effects are a function of the drug dose and drug concentration at the effect site [CLASSIFICATION OF DRUG ACTION] 4min Receptor mediated Drug action Receptors Ligands (Drugs) Ligand-receptor interaction -- effect Non-receptor mediated Drug action Physical property --effect Chemical property -- effect [DOSE-EFFECT ENDPOINTS] 5min Graded Continuous scale (dose--effect) Measured in a single biologic unit Relates dose to intensity of effect Quantal All-or-none pharmacologic effect Population studies Relates dose to frequency of effect [DRUG-RECEPTOR INTERACTIONS] 5min [DOSE-EFFECT CURVE] 3min Show some representative dose-effect curve and explain, such as: graded dose-effect curve, lidocaine graded dose-effect, theophylline dose-effect, metformin dose-response. [DOSE-EFFECT PARAMETERS] 3min