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.650, 北京科技大学学报 第29卷 therapy with adefovior dipivoxil for HBeAg negative chronic hep- [8]Perelson A S.Modelling viral and immune system dynamics.Nat atitis B.New England J Med.2005.352(26):2673 Rev Immunol.2002(2):28 [6]Nowak M J.Bonhoeffer S.Hill A M,et al.Viral dynamics in hep- [9]Min L Q.Dong X S.Research on viral dynamic models of hepati- atitis B virus infection.Proc Natl Acad Sci USA.1996.93:4398 tis B virus infection.J Univ Sci Technol Beijing.2004.11(6): [7]Lau G K.Tsiang M.Hou J.et al.Combination theory with 572 Lamivudine and Famciclovir for chronic Hepatitis Binfected Chi- [10]Min L Q.Dong X S.A viral dynamie CNN model of hepatitis B nese patients:a viral dynamics study.Hepathology.2000.39. virus infection.Dyn Continuous Discrete Implusive Syst Ser B. 394 2006,13(c):35 Dynamic mathematical model for adefovir dipivoxil anti-HBV treatment SU Yongmei),MIN Lequan2),ZHUO Xinjian 1)Applied Science School.University of Science and Technology Beijing,Beijing 100083.China 2)Information Engineering School.University of Science and Technology Beijing.Beijing 100083.China 3)Information Engineering School,Beijing University of Posts and Telecommunications,Beijing 100876,China ABSTRACT Based on over 180 HBeAg negative patients anti-HBV infection therapy data of adefovir dipivoxil with placebo for an international co-operation research and the HBV infection dynamic model proposed by Nowak et al,a mathematical model consisting of two differential equation systems was built.This model provided a pos- sible interpretation of the curative effect of adefovir dipivoxil with placebo for HbeAg negative chronic HBV in- fection patients,particularly explaining why the plasma virus of the patients turnover after stopping the adefovir dipivoxil therapy.This model predicts the long time adefovir dipivoxil curative effect that the patients whose plasma HBV DNAs is near the median values need to prolong treatment time until 5.6 years to delete HBV virus in bodies.This research implies also that the popular treatment standard of HBV DNA<500copiesmLis too rough to evaluate the effectiveness for aniti-HBV infection therapy. KEY WORDS adefovir dipivoxil;anti-HBV;mathematical model;curative effect predictiontherapy with adefovior dipivoxil for HBeAg-negative chronic hepatitis BNew England J Med2005352（26）：2673 ［6］ Nowak M JBonhoeffer SHill A Met al．Viral dynamics in hepatitis B virus infection．Proc Natl Acad Sci USA199693：4398 ［7］ Lau G KTsiang MHou J．et al．Combination theory with Lamivudine and Famciclovir for chronic Hepatitis B-infected Chinese patients：a viral dynamics study．Hepathology200039： 394 ［8］ Perelson A S．Modelling viral and immune system dynamics．Nat Rev Immunol2002（2）：28 ［9］ Min L QDong X S．Research on viral dynamic models of hepatitis B virus infection．J Univ Sci Technol Beijing200411（6）： 572 ［10］ Min L QDong X S．A viral dynamic CNN model of hepatitis B virus infection．Dyn Continuous Discrete Implusive Syst Ser B 200613（c）：35 Dynamic mathematical model for adefovir dipivoxil ant-i HBV treatment SU Yongmei 12）MIN Lequan 12）ZHUO Xinjian 3） 1） Applied Science SchoolUniversity of Science and Technology BeijingBeijing100083China 2） Information Engineering SchoolUniversity of Science and Technology BeijingBeijing100083China 3） Information Engineering SchoolBeijing University of Posts and TelecommunicationsBeijing100876China ABSTRACT Based on over180HBeAg negative patients’ant-i HBV infection therapy data of adefovir dipivoxil with placebo for an international co-operation research and the HBV infection dynamic model proposed by Nowak et ala mathematical model consisting of two differential equation systems was built．This model provided a possible interpretation of the curative effect of adefovir dipivoxil with placebo for HbeAg negative chronic HBV infection patientsparticularly explaining why the plasma virus of the patients turnover after stopping the adefovir dipivoxil therapy．This model predicts the long time adefovir dipivoxil curative effect that the patients whose plasma HBV DNAs is near the median values need to prolong treatment time until5∙6years to delete HBV virus in bodies．This research implies also that the popular treatment standard of HBV DNA＜500copies·mL －1is too rough to evaluate the effectiveness for anit-i HBV infection therapy． KEY WORDS adefovir dipivoxil；ant-i HBV；mathematical model；curative effect prediction ·650· 北 京 科 技 大 学 学 报 第29卷