9/15/2016 Bacteria acquire genes to become Food pathogens Horizontal transfer of blocks AN INTRODUCTION of virulence genes from a common microbial ancestor Bacterial Virulence leads to. brief overview Different pathogens use common strategies to cause infection and disease Emergence of new pathogens hgR金带Kal R.Mathew that are often resistant to multiple antibiotics Common strategies Adherence to host surfaces of pathogenicity the importance of first impressionis agents .Surfaces include skin,mucous membranes,deeper fissues prevention Adhesins prevent bacteria New effort is on from being washed away by or li mechanical forces produced by the host ance eria als 9/15/2016 1 Bacterial Virulence brief overview Bacteria acquire genes to become pathogens Horizontal transfer of blocks of virulence genes from a common microbial ancestor leads to…… • Different pathogens use common strategies to cause infection and disease • Emergence of new pathogens that are often resistant to multiple antibiotics Common strategies of pathogenicity • A thorough understanding is esesntial to develop better, novel vaccines and therapeutic agents for treatment and prevention • New effort is on identifying drugs that target virulence activities of pathogens instead of preventing their growth Adherence to host surfaces the importance of first impressions • Key step in host-pathogen interaction • Surfaces include skin, mucous membranes, deeper tissues • Adhesins prevent bacteria from being washed away by mechanical forces produced by the host • Biofilms are a common mechanism of adherance • Commensal bacteria also adhere to colonize the host