9/15/2016 Adhesins Invasion A bacterial surface protein induces endocytosis. Proteins Carbohydrates In the cell,some escape and others ‘6R865P8Esor comporents of cell wall multiply in the phagosome. cell membrane or capsule ‘ Bacteria inject proteins into the host cell causing cytoskelet al r engulfment of the bacteria. In the cytosol,bacteria lyse the vacuolar membrane,escape Escherichia coli P fimbrioe and move about in the host Cy十0s0. brush border ville brush border villi Invasion Evasion of host immunity Salmone/la bacteria produce invasins,proteins that cause the actin of the host cell's IgA proteases cytoskeleton to form a basket that carries the bacteria into the cell ilopodia assembly cannot protec 29/15/2016 2 Adhesins Proteins • Lipoproteins or glycoproteins • Often associated with fimbriae Carbohydrates • components of cell wall • cell membrane or capsule Vibrio cholerae rabbit intestinal brush border villi Escherichia coli calf intestinal brush border villi No capsule Capsule Escherichia coli P fimbriae Invasion Bacteria inject proteins into the host cell causing cytoskeletal reorganization and engulfment of the bacteria. In the cytosol, bacteria lyse the vacuolar membrane, escape, and move about in the host cytosol. A bacterial surface protein induces endocytosis. In the cell, some escape and others multiply in the phagosome. Invasion • Salmonella bacteria produce invasins, proteins that cause the actin of the host cell’s cytoskeleton to form a basket that carries the bacteria into the cell Evasion of host immunity IgA proteases