9/15/2016 Evasion of host immunity Evasion of host immunity Immunoglobulin-binding proteins Resist complement and protein A of 5.Aureus opsonisation helps inhibit phagocytic engulfment capsule,LPS,surface proteins acTs as an immunological disquise c1 complex Complement system:part of the immune system that enhances (complements)the ability of antibodie and phagocytic cells to clear microbes and damaged cells from an organism,promotes inflammation,and attacks membrane Evasion of host immunity Evasion of host immunity ·Antigenic mimicry .Antigenic or phase variation vary the structure of surface components ·Adopt a cryptic niche inside phagcytes or a biofilm mece 9/15/2016 3 Evasion of host immunity Immunoglobulin-binding proteins protein A of S. Aureus helps inhibit phagocytic engulfment acts as an immunological disguise Evasion of host immunity Resist complement and opsonisation capsule, LPS, surface proteins Complement system: part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and attacks membrane Evasion of host immunity Evasion of host immunity • Antigenic mimicry • Antigenic or phase variation vary the structure of surface components • Adopt a cryptic niche inside phagcytes or a biofilm