Plasma or Vesicular membrane PIP2 PI-3P P? Sperm CGE Egg PLC Membrane 6 c2 PLC Cortical Granules Vesicle PIP, NLS Ca2 Nucleus ER C2 Histidine>Leucine Histidine>Proline PLC position 233 position 398 InsP. (H233L) (H398P) ER PLC PLCC的作用模式和报道的突变位点PLCζ的作用模式和报道的突变位点