Allergen IgE FCERI FCERI S-S ① ③ 餐 PMT I) ④ PIP2 cyclase PMT D PE-PS Lyso PC DAG Phospho- Phospho lipase C PTK lipase A2 Degranulation PTK ATP cAMP (transient)T Fusogens PKC K (6 Protein kinase →Protein kinase (PKC) Active ⑦ inactive active Inactive PKC Swollen granule G2+ Microtubules ⑤ Granule Mediators and microfilaments (e.g..histamine) Arachidonic acid Leukotriene A Prostaglandin D2 Endoplasmic reticulum (P1D2) LTB4 LTC4 SRS-A LTD4 LTEA Secretion Secretion I型超敏反应发生的信号传导途径I型超敏反应发生的信号传导途径