Natural penicillins ·Penicillin G ·Pharmacokinetics: Easily destroyed by gastric acid Wide distribution and 5%across BBB when in meningitis Renal tubular excretion in prototypeNatural penicillins • Penicillin G • Pharmacokinetics: Easily destroyed by gastric acid Wide distribution and 5% across BBB when in meningitis Renal tubular excretion in prototype