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(收稿日期：20131209：修回日期：20140118) 9]Anacker C.Zunszain PA,Cattaneo A,et al.Antidepressants in- (责任编辑：左琦；英文编辑：张龙江) crease human hippocampal neurogenesis by activating the glu- ?1994-2015 China Academic Journal Electronic Publishing House.All rights reserved.http://www.cnki.net［25］ Whybrow PC，Prange AJ Jr． A hypothesis of thyroid-cate￾cholamine-receptor interaction． Its relevance to affective illness ［J］． Arch Gen Psychiatry，1981，38( 1) : 106-113． ［26］ 于 璟． 甲状腺功能与抑郁障碍关系的研究［D］． 大连理工 大学，2013． ［27］ Bambico FＲ，Belzung C． Novel insights into depression and anti￾depressants: a synergy between synaptogenesis and neurogenesis? ［J］Curr Top Behav Neurosci，2013，15( 3) : 243-291． ［28］ 胡益民，杨 春，周志强，等． N-甲基-D-天冬氨酸受体及其 亚型受体拮抗剂对抑郁大鼠的影响［J］． 医学研究生学报， 2012，25( 10) : 1012-1014． ［29］ EI Mansari M，Guiard BP，Chernoloz O，et al． Ｒelevance of norepinephrine-dopamine interactions in the treatment of major depressive disorder［J］． CNS Neurosci Ther，2010，16( 3) : 1- 17． ［30］ Mever JH． Neurochemical imaging and depressive behaviours ［J］． Curr Top Behav Neurosci，2013，14( 1) : 101-134． ［31］ Duman ＲS，Malberq J，Thome J． Neural plasticity to stress and antidepressant treatment［J］． Biol Psychiatry，1999，46 ( 9 ) : 1181-1191． ［32］ Shawn Hayley，Darcy Litteljohn． Neuroplasticity and the next wave of antidepressant strategies［J］． Front Cell Neurosci，2013， 7( 11) : 1-18． ［33］ Vitureira N，Goda Y． Cell biology in neuroscience: the interplay between Hebbian and homeostatic synaptic plasticity［J］． J cell Biol，2013，203( 2) : 175-186． ［34］ Ma DK，Marchetto MC，Guo JU，et al． Epigenetic choreograph￾ers of neurogenesis in the adult mammalian brain［J］． Nat Neu￾rosci，2010，13( 11) : 1338-1344． ［35］ Mu Y，Zhao C，Gage FH． Dopaminergic modulation of cortical inputs during maturation of adult-born dentate granule cells［J］． J Neurosci，2011，31( 11) : 4113-4123． ［36］ Aizawa K，Ageyama N，Terao K，et al． Primate-specific altera￾tions in neural stem / progenitor cells in the aged hippocampus ［J］． Neurobil aging，2011，32( 1) : 140-150． ［37］ Giachno C，Taylor V． Lineage analysis of quiescent regenerative stem cells in the adult brain by genetic labeling reveals spatially restricted neurogenic niches in the olfactory bulb［J］． Eur J Neu￾rosci，2009，30( 1) : 9-24． ［38］ Miles DK，Kernie SG． Hypoxic-ischemic brain injury activates early hippocampal stem / progenitor cells to replace vulnerable neuroblasts［J］． Hippocampus，2008，18( 8) : 793-806． ［39］ Anacker C，Zunszain PA，Cattaneo A，et al． Antidepressants in￾crease human hippocampal neurogenesis by activating the glu￾cocorticoid receptor［J］． Molecular Psychiatry，2011，16 ( 7) : 738-750． ［40］ Fuss J，Ben Abdallah NMB，Hensley FW，et al． Deletion of running-induced hippocampal neurogenesis by irradiation prevents development of an anxious phenotype in mice［J］． PLoS One， 2010，5( 9) : 12769-12783． ［41］ 王 楠，张广芬，周志强，等． 谷氨酸受体在抑郁症中的作 用［J］． 医学研究生学报，2012，25( 3) : 304-307． ［42］ Maggio N，Segal M． Differential modulation of long-term depres￾sion by acute stress in the rat dorsal and ventral hippocampus ［J］． J Neurosci，2009，29( 27) : 8633-8638． ［43］ Oliveira SL，Pillat MM，Cheffer A，et al． Functions of neurotro￾phins and growth factors in neurogenesis and brain repair［J］． Cytometry A，2013，83( 1) : 76-89． ［44］ Holsen LM，Lancaster K，Klibanski A，et al． HPA-Axis hor￾mone modulation of stress response circuitry activity in women with remittedmajor depression［J］． Neuroscience，2013，250 ( 10) : 733-742． ［45］ Ｒolls ET． The mechanisms for pattern completion and pattern separation in the hippocampus［J］． Front Syst Neurosci，2013，7 ( 10) : 1-21． ［46］ Piubelli C，Vighini M，Mathe AA，et al． Escitalopram modulates neuron-remodelling protein in a rat gene-evironment interaction model of depression as revealed by proteomics．［J］． Int J Neuro￾psychopharmacol，2011，14( 6) : 796-833． ［47］ Magni LＲ，Purgato M，Gastaldon C，et al． Fluoxetine versus other types of pharmacotherapy for depression［J］． Cochrane Da￾tabase Syst Ｒev，2013，17( 7) : 4185-4209． ［48］ Boldrini M，Underwood MD，Hen Ｒ，et al． Antidepressants in￾crease neural progenitor cells in the human hippocampus［J］． Neuropsychopharmacology，2009，34( 11) : 2376-2389． ［49］ Sahay A，Hen Ｒ． Adult hippocampal neurogenesis in depression ［J］． Nat Neurosci，2007，10( 9) : 1110-1115． ［50］ Wong J，Hyde TM，Cassano HL，et al． Promoter specific altera￾tions of brain-deribed neurotrophic factor mＲNA in schizophrenia ［J］． Neuroscience，2010，169( 3) : 1071-1084． ［51］ Vidal Ｒ，Pilar-Cuellar F，dos Anios S，et al． New strategies in the development of antidepressants: towards the modulation of neuroplasticity pathways［J］． Curr Pharm Des，2011，17 ( 5) : 521-523． ( 收稿日期: 2013-12-09; 修回日期: 2014-01-18) ( 责任编辑: 左 琦; 英文编辑: 张龙江) · 6331 · 医学研究生学报 2014 年 12 月 第 27 卷 第 12 期 J Med Postgra，Vol． 27，No． 12，December，2014