C. Antihypertensive Drugs Diuretics 1. Pharmacologicaleffects ()Reducing plasma volume (cardiac output l) (2) Reducing Na*-Ca2* exchange in vascular smooth muscle cells(Ca2+i L, peripheral resistance l)Diuretics 1. Pharmacological effects (1) Reducing plasma volume (cardiac output ) (2) Reducing Na+ -Ca2+ exchange in vascular smooth muscle cells (Ca2+ i , peripheral resistance  ) C. Antihypertensive Drugs