Classification of Antihypertensive Drugs by Their Primary Site or Mechanism of Action Diuretics( Chapter 29) 1. Thiazides and related agents(hydrochlorothiazide, chlorthalidone, etc 2. Loop diuretics(furosemide, bumetanide, torsemide, ethacrynic d 3.K+-sparing diuretics(amiloride, triamterene, spironolactone Sympatholytic Drugs(Chapters 9, 10, 34) 1. Centrally acting agents(methyldopa, clonidine, guanabenz, guanfacine) Noradrenergic 2. Adrenergic neuron blocking agents(guanadrel, reserpine) 3. B-Adrenergic antagonists(propranolol, metoprolol,etc nerve ending 4. a-Adrenergic antagonists(prazosin, terazosin, doxazosin blockers phenoxybenzamine, phentolamine) 5. Mixed adrenergic antagonists (labetalol, carvedilol Vasodilators( Chapter 34) 1. Arterial(hydralazine, minoxidil, diazoxide, fenoldopam 2. Arterial and venous(nitroprusside) Ca2t-Channel Blockers(Chapters 32, 34, 35)(verapamil, diltiazem nifedipine nimodipine, felodipine, nicardipine, isradipine, amlodipine) Angiotensin Converting Enzyme Inhibitors( Chapters 31, 32)(captopril, enalapril, lisinopril, quinapril, ramipril, benazepril, fosinopril moexipril, perindopril, trandolapril Angiotensin I1-Receptor Antagonists( Chapters 31, 34)(losartan, candesartan, irbesartan, valsartan, telmisartan, eprosartan)Noradrenergic nerve ending blockers