The Pathogenesis of Rheumatoid Arthritis NORMAL RHEUMATOID ARTHRmIS Inflamed Synovial membrane synovial membrane Major cell types Tlymphocy macrophages Pannus Alnor cell types: Cartilage plasma cells endothelium dendritic cells Capsule一 Synovial fluld Malor cell type Keystone E, et al. Rheum Dis Clin North Am. 1998: 24: 629-639: Fox DA. Arch Intem Med 2000: 160/437-444