D.Platelets E.Smooth muscle cells Ans:A The general sequence of atherosclerotic plaques is this:endothelial injury at lesion prone sites (low sheer stress,fluctuating flow)>macrophages adhere to injured endothelial and bring lipids foamy macrophages reduce growth factors to promote smooth muscle cell proliferation and inflammation mural thrombi stimulate PDGF>smooth muscle proliferation an matrix deposition formation of fibro-inflammatory lipid plaque with central necrotic core:Platelets and lymphocytes do not play a role in plaque formation. 11.A 59-year-old man has experienced chest pain at rest for over one year.He develops crushing chest pain,collapses and dies due to arrhythmia.The figure above shows a cross section of his left anterior descending artery.Which of the following laboratory findings has a causal relationship to this lesion? A.Absent C-reactive protein B.Inherited deficiency in VEGF C.Low HDL cholesterol D Low total se n cholesterol E.Positive VDRL Ans:C Elevated HDL is associated with decreased risk of coronary artery disease,thus low HDL is likely in this patient.CRP has been associated with cardiovascular disease but it is non-specific. D. Platelets E. Smooth muscle cells Ans: A The general sequence of atherosclerotic plaques is this: endothelial injury at lesion prone sites (low sheer stress, fluctuating flow) macrophages adhere to injured endothelial and bring lipids foamy macrophages reduce growth factors to promote smooth muscle cell proliferation and inflammation mural thrombi stimulate PDGF smooth muscle proliferation an matrix deposition formation of fibro-inflammatory lipid plaque with central necrotic core; Platelets and lymphocytes do not play a role in plaque formation. 11. A 59-year-old man has experienced chest pain at rest for over one year. He develops crushing chest pain, collapses and dies due to arrhythmia. The figure above shows a cross section of his left anterior descending artery. Which of the following laboratory findings has a causal relationship to this lesion? A. Absent C-reactive protein B. Inherited deficiency in VEGF C. Low HDL cholesterol D. Low total serum cholesterol E. Positive VDRL Ans: C Elevated HDL is associated with decreased risk of coronary artery disease, thus low HDL is likely in this patient. CRP has been associated with cardiovascular disease but it is non-specific