D.Platelets E.Smooth muscle cells Ans:A The general sequence of atherosclerotic plaques is this:endothelial injury at lesion prone sites (low sheer stress,fluctuating flow)>macrophages adhere to injured endothelial and bring lipids foamy macrophages reduce growth factors to promote smooth muscle cell proliferation and inflammation mural thrombi stimulate PDGF>smooth muscle proliferation an matrix deposition formation of fibro-inflammatory lipid plaque with central necrotic core:Platelets and lymphocytes do not play a role in plaque formation. 11.A 59-year-old man has experienced chest pain at rest for over one year.He develops crushing chest pain,collapses and dies due to arrhythmia.The figure above shows a cross section of his left anterior descending artery.Which of the following laboratory findings has a causal relationship to this lesion? A.Absent C-reactive protein B.Inherited deficiency in VEGF C.Low HDL cholesterol D Low total se n cholesterol E.Positive VDRL Ans:C Elevated HDL is associated with decreased risk of coronary artery disease,thus low HDL is likely in this patient.CRP has been associated with cardiovascular disease but it is non-specific. D. Platelets E. Smooth muscle cells Ans: A The general sequence of atherosclerotic plaques is this: endothelial injury at lesion prone sites (low sheer stress, fluctuating flow)  macrophages adhere to injured endothelial and bring lipids  foamy macrophages reduce growth factors to promote smooth muscle cell proliferation and inflammation  mural thrombi stimulate PDGF  smooth muscle proliferation an matrix deposition  formation of fibro-inflammatory lipid plaque with central necrotic core; Platelets and lymphocytes do not play a role in plaque formation. 11. A 59-year-old man has experienced chest pain at rest for over one year. He develops crushing chest pain, collapses and dies due to arrhythmia. The figure above shows a cross section of his left anterior descending artery. Which of the following laboratory findings has a causal relationship to this lesion? A. Absent C-reactive protein B. Inherited deficiency in VEGF C. Low HDL cholesterol D. Low total serum cholesterol E. Positive VDRL Ans: C Elevated HDL is associated with decreased risk of coronary artery disease, thus low HDL is likely in this patient. CRP has been associated with cardiovascular disease but it is non-specific