Anti-neoplastic drugs that block VEGF have cardiac toxicity.but inherited deficiency of VEGF exists only in a few case reports of hereditary lymphedema or mouse models demonstrating embryonic cardiovascular failure.The total cholesterol to HDL ratio is a better predictor of coronary artery disease than serum cholesterol alone.A positive VRDL would indicate syphilis or one of the many false positive conditions (HIV.SLE,malaria,Lyme disease). 12.A 12-year-old boy died of complications of acute lymphocytic leukemia.An autor sy was Are debris covered byacapof smooth musce cells A d c lation and hemorrhag cells and macrophages Ep调本d Ans:E The photograph shows a fatty streak,a flat lesion in the intima that contains accumulations of lipid.These are common even in voung children.subsequent stages of atherosclerotic plaque formation are represented by features such as a core of lipid debris covered by a cap of smooth muscle cells:cholesterol clefts surrounded by smooth muscle cells and macrophages;a lipid core,granulation tissue and hemorrhage and foam cells (macrophages),areas of necrosis and calcification.Anti-neoplastic drugs that block VEGF have cardiac toxicity, but inherited deficiency of VEGF exists only in a few case reports of hereditary lymphedema or mouse models demonstrating embryonic cardiovascular failure. The total cholesterol to HDL ratio is a better predictor of coronary artery disease than serum cholesterol alone. A positive VRDL would indicate syphilis or one of the many false positive conditions (HIV, SLE, malaria, Lyme disease). 12. A 12-year-old boy died of complications of acute lymphocytic leukemia. An autopsy was performed and his aorta is shown above. Histologic examination of the area marked by the arrow is most likely to show which of the following features? A. A core of lipid debris covered by a cap of smooth muscle cells B. A lipid core, granulation tissue and hemorrhage C. Cholesterol clefts surrounded by smooth muscle cells and macrophages. D. Foam cells (macrophages), areas of necrosis and calcification. E. Lipid filled myointimal cells Ans: E The photograph shows a fatty streak, a flat lesion in the intima that contains accumulations of lipid. These are common even in young children. Subsequent stages of atherosclerotic plaque formation are represented by features such as a core of lipid debris covered by a cap of smooth muscle cells; cholesterol clefts surrounded by smooth muscle cells and macrophages; a lipid core, granulation tissue and hemorrhage and foam cells (macrophages), areas of necrosis and calcification