Complexities of the Nomenclature:Example Modes of action of pesticides: Disturbance in energy production Chemical Name Inhibition of photosynthesis ) Free radical generation SH-group reactivity Interference with cell division Inhibition of nucleic acid synthesis Inhibition of enzymes: Ergosterol synthesis Amino acid synthesis 级4，ENT游 Varies Codes Chitin synthesis Cholinesterase Hormone-like and behavior-modifying agents 1.h des:Mode af Action and Teod ogr.CRE Press 2004 Disturbance in energy production Disturbance in energy production Site of Action Compounds Toic for Most animals C e-al Most animals (o ate) Rotenon Insects,fish B.O ic rgnm Most arganisms Naturally occurring compound ts.fis Highly toxic to fish them to CRC Ps 2004 3 Complexities of the Nomenclature: Example Stenersen, J. Chemical pesticides: Mode of Action and Toxicology. CRC Press 2004 • Disturbance in energy production • Inhibition of photosynthesis • Free radical generation & SH-group reactivity • Interference with cell division • Inhibition of nucleic acid synthesis • Inhibition of enzymes: Ergosterol synthesis Amino acid synthesis Chitin synthesis Cholinesterase • Hormone-like and behavior-modifying agents Modes of action of pesticides: Disturbance in energy production Naturally occurring compound Blocks electron transfer from NADH to ubiquinone in mitochondria Highly toxic to fish Stenersen, J. Chemical pesticides: Mode of Action and Toxicology. CRC Press 2004 Disturbance in energy production Stenersen, J. Chemical pesticides: Mode of Action and Toxicology. CRC Press 2004