Acid-Base Reaction to Form Enolate Very strong base is required for complete reaction.Example: CHs CH, CH,一C CH一C N-一H C.H Li CaH10 CN: Li计 CH3-CH n-butyllithium butane CH:-CH CH CH; diisopropylamine lithium diisopropylamide (LDA) Copyright 2005 Pearson Prentice Hall,Inc. O-Lit (i-CH)N-Li+ (i-C,H)2N-H cyclohexanone LDA lithium enolate (pK,=36 (pK.=I19) => of cyclohexanone 10 (100%) Copyright 2005 Pearson Prentice Hall,Inc.Chapter 22 10 Acid-Base Reaction to Form Enolate Very strong base is required for complete reaction. Example: =>