“二次打击”学说 FLT3-ITD PML/RARC FLT3 D835Y Associated with a block Confer proliferative and/or haematopoietic differentiation at survival advantage, but do not the promyelocyte stage, affect differentiation not sufficient to cause APl RX FLT3 inhibitors APL ATRA D. Gary Gilliland Best Practice& Research Clinical Haematology. 2003, 16. 409-417“二次打击”学说 D.Gary Gilliland Best Practice & Research Clinical Haematology.2003;16:409-417