安徽医科大学国际教育学院教案与讲稿 Drug B Plasma Tissue Drug A protein bound 川 Drug A DrugA free free Drugs Aand B both bind to the same plasma protein Drug Transport Proteins:Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol 3.Metabolism Drug Metabolism Interactions:Induction Warfarin Diazepam CYP2C9 Beneficial Use of Induction Drug Metabolism Interactions:Inhibition Gefitinib AUC83%↓ AUC80%↑ ⊙ Rifampin CYP3A4 Itraconazole O-desmethyl-gefitinib 4.excretion Drug A increases or reduces the excretion (usually renal)of Drug B. Blood levels of B fall below or rise above normal therapeutic range. Becomes either ineffective or toxic. IPHARMACODYNAMICS DRUG INTERACTIONSI 13min 1.Synergistic combinations ● Pharmacologic effect>than the summation of the 2 drugs Beneficial:aminoglycoside penicillin Harmful:barbiturates alcohol 2.Antagonism Pharmacologic effect than the summation of the 2 drugs Beneficial:naloxone in opiate overdose安徽医科大学国际教育学院教案与讲稿 3
Drug Transport Proteins: Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol 3. Metabolism
Drug Metabolism Interactions: Induction
Beneficial Use of Induction
Drug Metabolism Interactions: Inhibition 4. excretion
Drug A increases or reduces the excretion (usually renal) of Drug B.
Blood levels of B fall below or rise above normal therapeutic range.
Becomes either ineffective or toxic. [PHARMACODYNAMICS DRUG INTERACTIONS] 13min 1. Synergistic combinations
Pharmacologic effect > than the summation of the 2 drugs
Beneficial: aminoglycoside + penicillin
Harmful: barbiturates + alcohol 2. Antagonism
Pharmacologic effect < than the summation of the 2 drugs
Beneficial: naloxone in opiate overdose