安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Drug Interactions Chapter:15 Teacher's name:Qiong Huang Grade:2013 Department:Clinical Medicine,School of International Education Time:14:30-16:50 Date(D/M/Y):3/16/2016 Lecture Notes: [MODULES] 2min MODULE 1:Introduction to drug interactions MODULE 2:The types of Drug Interactions MODULE 3:Pharmacokinetic Drug Interactions MODULE 4:Pharmacodynamics Drug Interactions MODULE 5:Questions and discussion JINTRODUCTION TO DRUG INTERACTIONSI 3min 1.DRUG INTERACTIONS:The pharmacological result,either desirable or undesirable,of drugs interacting with themselves or with other drugs,with endogenous chemical agents,with components of the diet,or with chemicals used in or resulting from diagnostic tests. 2.RESULT OF DRUG INTERACTION To increase theraputic efficacy and decrease toxicity To decrease theraputic efficacy and increase toxicity [TYPES OF DRUG INTERACTIONS] 5min 1.Pharmacokinetic What the body does with the drug One drug alters the concentration of another by altering its absorption,distribution. metabolism,or excretion Usually (but not always)mediated by cytochrome P450(CYP) 2.Pharmacodynamic Related to the drug's effects in the body One drug modulates the pharmacologic effect of another:additive synergistic,or antagonistic 3.Interaction in vitro intravenous admixture [PHARMACOKINETIC DRUG INTERACTIONSI 13min 1.absorption ·pH Anion exchange resins ·Food 2.distribution Protein Binding Interactions 2安徽医科大学国际教育学院教案与讲稿 2 Teaching Plan for International Students, AHMU Title of the course: Drug Interactions Chapter: 15 Teacher’s name: Qiong Huang Grade: 2013 Department: Clinical Medicine, School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/16/2016 Lecture Notes: [MODULES] 2min MODULE 1: Introduction to drug interactions MODULE 2: The types of Drug Interactions MODULE 3: Pharmacokinetic Drug Interactions MODULE 4: Pharmacodynamics Drug Interactions MODULE 5: Questions and discussion [INTRODUCTION TO DRUG INTERACTIONS] 3min 1. DRUG INTERACTIONS: The pharmacological result, either desirable or undesirable, of drugs interacting with themselves or with other drugs, with endogenous chemical agents, with components of the diet, or with chemicals used in or resulting from diagnostic tests. 2. RESULT OF DRUG INTERACTION
To increase theraputic efficacy and decrease toxicity
To decrease theraputic efficacy and increase toxicity [TYPES OF DRUG INTERACTIONS] 5min 1. Pharmacokinetic
What the body does with the drug
One drug alters the concentration of another by altering its absorption, distribution, metabolism, or excretion
Usually (but not always) mediated by cytochrome P450 (CYP) 2. Pharmacodynamic
Related to the drug’s effects in the body
One drug modulates the pharmacologic effect of another: additive,
synergistic, or antagonistic 3. Interaction in vitro
intravenous admixture [PHARMACOKINETIC DRUG INTERACTIONS] 13min 1. absorption
pH
Anion exchange resins
Food 2. distribution
Protein Binding Interactions