No of Pages 9 06 September 2019 ARTICLE IN PRESS Cheng Wang et al. / Neuroscience 418(2019)XXx-XXX Bannerman DM. Deacon RM. Offen S Friswell J. Grubb M. Rawlins JN 2002)Double dissociation of function within the hippocampus: spati 64(10)884890,https://doi.org/10.1016/biopsy.2008.06016 memory and hyponeophagia Behav Neurosci 116(5) 884-901 Gouveia A, dos Santos UD, Felisbino FE, de Fonseca TL, Antunes Bannerman DM, Grubb M, Deacon RM. Yee BK, Feldon J, Rawlins JN lorato S(2004)Influence of the estrous cycle on the behavior (2003)Ventral hippocampal lesions affect anxiety but not spatial rats in the elevated T-maze. Behav Processes 67(2): 167-171 arning. Behav Brain Res 139(1-2): 197-213 ps/ doi. org/10.1016 eprom.2004.03.018 Bannerman DM, Rawlins JN, McHugh SB, Deacon RM, Yee BK, BastT, Hakamata Y, Iwase M, Iwata H, Kobayashi T, Tamaki T, Nishio M, Feldon J(2004)Regional dissociations within the hippocampus nada T(2009)Gender difference in relationship between anxiety- related personality traits and cerebral brain glucose metabolism j/doi. org/10.1016/j. neubiorev 2004.03.004 PsychiatryRes173(3):206-211,https://doi.org/10.1016/j Bath KG, Chuang J, Spencer-Segal JL, Amso D, Altemus M, McEwen pscychresns. 2008. 10.002 BS, Lee FS(2012)Variant brain-derived neurotrophic factor(Vali- Herbert J, Goodyer IM, Grossman AB, Hastings MH, de Kloet ER, Light- e66Methionine)polymorphism contributes to developmental and man SL, Seckl JR(2006)Do corticosteroids damage the brain? J estrous stage-specific expression of anxiety-like behavior in female Neuroendocrinol18(6):393-411,https://doi.org/10.1111/-1365 niceBiolPsychiatry72(6):499-504,https://doi.org/10.1016/j 2826.2006.01429X. Herman JP, Cullinan WE(1997)Neurocircuitry of stress: central control Baxter AJ, Scott KM, Vos T, Whiteford HA.(2013)Global prevalence of of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci anxiety disorders: a systematic review and meta-regression. Psychol Med43(5)897-910,htps/ doi. org/10.1017003329171200147X Ingalhalikar M, Smith A, Parker D, Satterthwaite TD, Elliott MA, Ruparel Bhatnagar S, Vining C, Denski K(2004)Regulation of chronic stress- K, Verma R(2014)Sex differences in the structural connectome of induced changes in hypothalamic-pituitary-adrenal activity by the thehumanbrainprOcNatlAcadSciuSa111(2):823-828,https:// basolateralamygdalaAnnNyAcadSci1032:315-319,https:// doi. org/10.1073pnas.1316909110 Jacobson L, Sapolsky R(1991)The role of the hippocampus in feed Bourke Ch. Raee Malviya S, Bradbum CA, Binder EB, Neigh GN back regulation of the hypothalamic-pituitary-adrenocortical axis. (2013)Glucocorticoid sensitizers Bag1 and Ppid are regulated by ado- EndocrRev12(2):118-134,https://doi.org/10.1210/edrv-12-2-118 scent stress in a sex-dependent manner. Psychoneuroendocrinology Jiang YY, Zhang Y, Cui S, Liu FY, Yi M, Wan Y(2018)Cholinergic neu B(1)84-93,https://doi.org/10.1016/-psyneuen.2012.05.001 rons in medial septum maintain anxiety-like behaviors induced by quzca LA, Swanson LW.(2007)Spatial organization of direct hippocam- chronicinflammatorypainNeurosciLett671:7-12,https://doi.org field CAl axonal projections to the rest of the cerebral cortex. Brai 10.1016 neulet2018.01.041 ResRev56(1)1-26,https://doiorg/10.1016/jbrainresrev.2007.05.002. Jimenez JC, Su K, Goldberg AR, Luna VM, Biane JS, Orde G, Kheir- Craske MG, Stein MB (2016)Anxiety. Lancet 388(10063) 3048-3059 bek MA.(2018) Anxiety cells in a hippocampal-hypothalamic circuit https://doiorg/10.1016/501406736(1630381 Neuron97(3):670-683e676https://doi.org/10.1016/j.neuron2018 Davidson RJ.(2002) Anxiety and affective style: role of prefrontal cortex and amygdala. Biol Psychiatry 51(1): 68-80 Jinks AL, McGregor IS. (1997) Modulation of anxiety-related behaviours avis M. 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