FACTORS THAT CAN PREVENT REGENERATION Size of defect e, g bone does not regenerate in large defects Collapse of surrounding tissue into the defect e g, periodontal defects Excessive strains in the reparative tissue e.g unstable le fracturesFACTORS THAT CAN PREVENT FACTORS THAT CAN PREVENT REGENERATION REGENERATION • Size of defect Size of defect – e.g., bone does not regenerate in large defects ., bone does not regenerate in large defects • Collapse of surrounding tissue into the Collapse of surrounding tissue into the defect – e.g., periodontal defects ., periodontal defects • Excessive strains in the reparative tissue Excessive strains in the reparative tissue – e.g., unstable fractures ., unstable fractures