Chromosome Disorders Are a major Category of Genetic Disease Large proportion of Reproductive wastage(miscarriages) Congenital malformations Mental retardation Significant role in pathogenesis of malignancyChromosome Disorders Are A Major Category of Genetic Disease • Large proportion of: – Reproductive wastage (miscarriages) – Congenital malformations – Mental retardation • Significant role in pathogenesis of malignancy