Chromosome Disorders Are a major Category of Genetic Disease Specific chromosomal abnormalities are: Responsible for >100 identifiable syndromes Collectively more common than all of the Mendelian single gene disorders together!Chromosome Disorders Are A Major Category of Genetic Disease • Specific chromosomal abnormalities are: – Responsible for >100 identifiable syndromes – Collectively more common than all of the Mendelian single gene disorders together!