Central nervousNervousness: hyperkinesia; emotional Lethargy: general slowing of mental system lability processes: neuropathies Musculoskeletal Weakness and muscle fatigue Stiffness and muscle fatigue decreased system Increased deep tendon reflexes deep tendon reflexes: increased alkaline hypercalcemia: osteoporosis phosphatase LDH. AST Renal system Mild polyuria: increased renal blood Impaired water excretion:decreased flow increased glomerular filtration renal blood flow decreased glomerular rate filtration rate Hematopoietic Increased erythropoiesis: anemia Decreased erythropoiesis; anemia' Reproductive Menstrual iregularities; decreasedHypermenorrhea: infertility: decreased system fertility; increased gonadal steroid libido; impotence; oligospermia metabolism decreased gonadal steroid metabolism Metabolic Increased basal metabolic rate Decreased basal metabolic rate: slight system negative nitrogen balance positive nitrogen balance; delayed hyperglycemia: increased free fatty degradation of insulin, with increased acids; decreased cholesterol and sensitivity; increased cholesterol and triglycerides: increased hormone triglycerides: decreased hormone degradation: increased requirements degradation: decreased requirements for for fat- and water-soluble vitamins: fat- and water-soluble vitamins increased drug metabolism decreased drug metabolism