System Thyrotoxicosis Hypothyroidism Skin and Warm, moist skin; sweating: heat Pale, cool, puffy skin: dry and brittle engages intolerance: fine, thin hair: Plummer's hair: brittle nails nails: pretibial dermopathy( graves disease) Eyes. face Retraction of upper lid with wide Drooping of eyelids; periorbital edema stare: periorbital edema loss of temporal aspects of eyebrows exophthalmos;diplopia(Graves' puffy, nonpitting facies; large tongue disease Cardiovascular Decreased peripheral vascular Increased peripheral vascular resistance system resistance, increased heart rate, stroke decreased heart rate, stroke volume volume, cardiac output, pulse cardiac output, pulse pressure; low pressure; high-output heart failure; output heart failure; ECG: bradycardia, increased inotropic and chronotropic prolonged PR interval, flat T wave, low eIfects, aRrhythmias angina voltage:pericardial effusion Respirator Dyspnea; decreased vital capacity Pleural effusions; hypoventilation and system CO, retention Gastrointestinal Increased appetite: increased Decreased appetite: decreased frequency system frequency of bowel movements of bowel movements: ascites ypoproteinemia