第2期 张雅斌等:诺氟沙星在鱼类细菌性疾病中的应用研究 85 [8]陈文银,卯春华,诺氟沙星在中华鳖体内的药代动力学研究水产学报,1997,21(4):434-437 [9]陈四清,饲喂土霉素对鲤鱼生长及代谢残留的研究].饲料工业,1997,18(5):19 [10]冯淇辉,兽医药物代谢动力学[M].北京:科学出版社,198 11]张祚新张雅斌郑伟,等,诺氟沙星在鲤鱼体内的药代动力学[J]中国兽医学报,200020(1):66-69 pplication of norfloxacin in treatment of bacterial diseases in fishes ZHANG Yar. ZHAN G Zuoxin2. ZHENG Wei. LIU Yarrhui' (1. Jilin Privince Aquatic Scientific Insitute, Ciangchun 130051 ary Veterinary Institute, University of Agriculture and Ariima Sciences, Changchun 130062) Abstract: Norfloxacin of the seven bacteriostasis drugs tested is the highest sensitive(MIc p <0. 2 Hg/mL) to Noxfloxacin pathogenic bacteria infection bacterial hemorrhagic septicemia in Carp. The experiment of internal antic- bacteria effect showed that Norfloxacin eit her il jected into the fish at 1 mg/ kg or oral administration at 10 mg/ kg has the desired action such as improving the survival rate of infected fish. The effect of p harmaco kinetics research shows that the drug level in the fishs blood is upto 0. 2 Hg/ mL, during the course of taking drug mixed in diet 0. 75 h to 24 h. On the basis of the experiment, the administration of drug is established, that is, the dose orally is 10 mg/kg, at the intervals of 24 h for 5 times. The effect applied in production is good. The poisonous test, pouring impatientty Norfloxacin down the throat with Carp, shows LD5o>1000 mg/kg(96 h). There was no remains of the Norflo xacin in the muscle after administration of 144 h Key words Norfloxacin; effect of autisepic drug; scheme of taking drug; fish bacterial disease 201994-2007ChinaAcademicJOurnalElectronicPublishinghOuse.Allrightsreservedhttp:/www.cnki.net[ 8 ] 陈文银 ,卯春华 1 诺氟沙星在中华鳖体内的药代动力学研究[J ]1 水产学报 ,1997 ,21 (4) :434 - 4371 [ 9 ] 陈四清 1 饲喂土霉素对鲤鱼生长及代谢残留的研究[J ]1 饲料工业 ,1997 , 18 (5) :19 - 201 [ 10 ] 冯淇辉 1 兽医药物代谢动力学[ M ]1 北京 :科学出版社 ,19871 [ 11 ] 张祚新 ,张雅斌 ,郑伟 ,等 1 诺氟沙星在鲤鱼体内的药代动力学[J ]1 中国兽医学报 ,2000 ,20 (1) :66 - 691 Application of Norfloxacin in treatment of bacterial diseases in f ishes ZHAN G Ya2bin1 , ZHAN G Zuo2xin2 , ZHEN G Wei1 , L IU Yan2hui1 (11Jilin Privince Aquatic Scientific Institute , Changchun 130051 ; 21Military Veterinary Institute , University of Agriculture and Animal Sciences , Changchun 130062 ) Abstract : Norfloxacin of the seven bacteriostasis drugs tested is the highest sensitive (M ICρ < 012μg/ mL) to Noxfloxacin pathogenic bacteria infection bacterial hemorrhagic septicemia in Carp1 The experiment of internal antic - bacteria effect showed that Norfloxacin either in2 jected into the fish at 1 mg/ kg or oral administration at 10 mg/ kg has the desired action such as improving the survival rate of infected fish. The effect of pharmacokinetics research shows that the drug level in the fish’s blood is upto 012μg/ mL , during the course of taking drug mixed in diet 0175 h to 24 h1 On the basis of the experiment , the administration of drug is established , that is , the dose orally is 10 mg/ kg , at the intervals of 24 h for 5 times1 The effect applied in production is good1 The poisonous test , pouring impatientty Norfloxacin down the throat with Carp , shows LD50 > 1000 mg/ kg (96 h) 1 There was no remains of the Norfloxacin in the muscle after administration of 144 h. Key words :Norfloxacin ; effect of autisepic drug ; scheme of taking drug ;fish bacterial disease 第 2 期 张雅斌等 : 诺氟沙星在鱼类细菌性疾病中的应用研究 58