ROSETTA- the most successful approach to ab initio prediction David Baker, U. Washington, Seattle Based on the idea that the possible conformations of any short peptide fragment(3-9 residues) are well represented by the structures it is observed to adopt in the pdb Generate a library of different possible structures for each sequence segment Search the possible combinations of these for ones that are protein-like by various criteriaROSETTA - the most successful approach to ab initio prediction • David Baker, U. Washington, Seattle • Based on the idea that the possible conformations of any short peptide fragment (3-9 residues) are well￾represented by the structures it is observed to adopt in the pdb • Generate a library of different possible structures for each sequence segment • Search the possible combinations of these for ones that are protein-like by various criteria