国生 国生 Comen variation 国生 Package Foc covenien of handnguse,and for protection purposes,drug products are always packaged in containers for marketing. Product stability may be imp Poor blending Hard granules design,and proper use of con Formulation design itself may not be always Tfer of water solbe ingdient sufficientto ensure that the product is stable during Poor solubility of active ingredient storage. Some drug products require protection against degrading factors,such as humidity and oxygen 国生 Package Permeable containers 通性质稳定、易成形药物的片科复方瑞孩甲基异零座片 ©不稳定药物的片剂复方阿司匹林片 Polyvin四chloride(C氯乙场) ·乙酰水柄 288g ·Polyvimy dichleride(PVDC聚二氧乙桶)blisters 400g ·对乙酰基酚（扑格息痛） 138 ·Polyethylene1 epbchalate(PET聚乙烯对装二中酸盾)bea 。三甲氧苄氨晓 (TMP) ·壶啡因 33.4g ·High density polyehene (HDPE高密度聚乙烯)bottles ·淀粉 40g ·淀粉 268g ·10%淀粉装 24g ·淀粉菜《15%一17%) Glass bottles ·干淀粉 23g(4%左右) 。清石粉 25g(5%) ·硬而酸碳 3g(0.5%左右) ·轻质体石蜡 ·制线100片（每片含S20.4 清石酸 ·制成1000片 ®小剂量药物的片剂硝酸甘油片 ®©中药片潮当归浸膏片 ·乳糖 888阳 ·当归浸音 ·糖松 380g ·淀粉 ·17%淀粉装 适量 ·轻质氧化 Coating 10%确酸甘油乙醇溶液 0.6(硝眼甘油量) ·硬酸钱 1.0g ·带石粉 80g ·制成1000片（每片含确酸甘油0.5mg》 ·制成1000片 1616 Shanghai Jiao Tong University Failure of dissolution Poor disintegration Hard granules Poor solubility of active ingredient Shanghai Jiao Tong University Content variation Weight variation Poor blending Transfer of water soluble ingredient Shanghai Jiao Tong University Package For convenient of handling, use, and for protection purposes, drug products are always packaged in containers for marketing. Product stability may be imparted by formulation design, and proper use of containers. Formulation design itself may not be always sufficient to ensure that the product is stable during storage. Some drug products require protection against degrading factors, such as humidity and oxygen. Shanghai Jiao Tong University Package Permeable containers • Polyvinyl chloride (PVC聚氯乙烯) blisters • Polyvinyl dichloride (PVDC聚二氯乙烯) ) blisters • Polyethylene terephthalate (PET聚乙烯对苯二甲酸酯) bottles • High density polyethylene (HDPE高密度聚乙烯) bottles Impermeable containers • Glass bottles • Aluminum foil Shanghai Jiao Tong University 性质稳定、易成形药物的片剂-复方磺胺甲基异恶唑片 • 磺胺甲基异恶唑（SMZ） 400g • 三甲氧苄氨嘧啶（TMP） 80g • 淀粉 40g • 10%淀粉浆 24g • 干淀粉 23g（4%左右） • 硬脂酸镁 3g（0.5%左右） • 制成1000片（每片含SMZ 0.4g） Shanghai Jiao Tong University 不稳定药物的片剂-复方阿司匹林片 • 乙酰水杨酸（阿司匹林） 268g • 对乙酰氨基酚（扑热息痛） 136g • 咖啡因 33.4g • 淀粉 266g • 淀粉浆（15%～17%） 85g • 滑石粉 25g（5%） • 轻质液体石蜡 2.5g • 酒石酸 2.7g • 制成1000片 Shanghai Jiao Tong University 小剂量药物的片剂-硝酸甘油片 • 乳糖 88.8g • 糖粉 38.0g • 17%淀粉浆 适量 • 10%硝酸甘油乙醇溶液 0.6g（硝酸甘油量） • 硬脂酸镁 1.0g • 制成1000片（每片含硝酸甘油0.5mg） Shanghai Jiao Tong University 中药片剂-当归浸膏片 • 当归浸膏 262g • 淀粉 40g • 轻质氧化镁 60g • 硬脂酸镁 7g • 滑石粉 80g • 制成1000片 Coating