国t生Why cat tablets? 国生 Tablet properties 国生一 Coated tablets Protect the medicinal aen Smooth surface Mask the taste ©sical shape ©Sugar coating ©Film coating Separate reactive substances Mechanical strength ©Compression coting Provide estheticsrdis 国4生Sugar-coatedtablets 国24线Film-coaintablcts Film-coating places a thin skin-tight coating ofa @Fl色-forming po山er得粮衣材料 plastic-like mav the compdtablet. 增塑剂 In contrast to sugar coating,film-coating only Pore material 致孔剂 dds up to5%weight to the final tablet,with a 抗整剂 negligible increase in tahlet size. 剂 hhn 图tt生下ilm-fomnpolymer Plasticizer Pore material G小cem甘油 Sodium chloride EG聚乙二醇 G小y:ei通甘油三酯酸霜 Surfactants Dibutyl sebocate二丁基二酸 PEG Csor花麻油 Corn oil3玉米泊 Others 1717 Shanghai Jiao Tong University Why coat tablets? Protect the medicinal agent Mask the taste Separate reactive substances Provide esthetics or distinction Provide special release characteristics Shanghai Jiao Tong University Tablet properties Smooth surface Physical shape Mechanical strength Shanghai Jiao Tong University Coated tablets Sugar coating Film coating Compression coating Shanghai Jiao Tong University Sugar-coated tablets Sealing coat: prevent coating solution penetration into the core Subcoat: round off the sharp corners of the tablet to produce a smooth surface Smoothing coat: provides the tablet with a smooth finish. Coloring: lakes often being preferred because a uniform colour is easier to achieve with them Polishing: transferred to a polishing pan and coated with to provide a glossy finish to the surface Shanghai Jiao Tong University Film-coating tablets Film-coating places a thin skin-tight coating of a plastic-like material over the compressed tablet. In contrast to sugar coating, film-coating only adds up to 5% weight to the final tablet, with a negligible increase in tablet size. Shanghai Jiao Tong University Ingredients of Film-forming solutions Film-forming polymer薄膜衣材料 Plasticizer 增塑剂 Pore material 致孔剂 Antiadherent 抗黏剂 Colorant and opacifier着色剂和遮光剂 Solvents 溶剂 Shanghai Jiao Tong University Film-forming solutions polymer Materials used for ordinary coating • HPMC羟丙基甲基纤维素 • MC甲基纤维素 • HEC羟乙基纤维素 • HPC羟丙基纤维素 Materials used for sustained release • Acrylate acid resin丙烯酸树脂 • EC乙基纤维素 • Cellulose acetate醋酸纤维素 Materials used for enteric coating • CAP醋酸纤维素酞酸酯 • PVAP聚乙烯醇酞酸酯 • Polymers of methacrylic acid and its esters 甲基丙烯酸共聚物 • CAT醋酸纤维素苯三酸酯 • HPMCP羟丙基纤维素酞酸酯 • Acrylate acid resin丙烯酸树脂 Shanghai Jiao Tong University Plasticizer Glycerin甘油 Propylene glycol丙二醇 PEG聚乙二醇 Cocoanut oil椰子油 Castor oil蓖麻油 Corn oil玉米油 Liquid paraffin液体石蜡 Glycerin monoacetate甘油单醋酸酯 Glycerin triacetate甘油三醋酸酯 Dibutyl sebacate二丁基癸二酸酯 Dibutyl Phthalate邻苯二甲酸二丁酯 Others Shanghai Jiao Tong University Pore material Sucrose Sodium chloride Surfactants PEG