国生 Solvents ④生Aqueous polymeric dispersions 象Ethanol 围Latexes胶乳 ®1 sopropanol ©Low viscosity 思Pseudolatexes伪敢乳 Acetone ®High polymer content Micronized polymeric powder粉末分收物 Water ©Productive 图a经Mechanism offmformation ©24一Aqueous polymeric dispersions 国生A9 olymersr Polymer Brand Polymer component 妆 Acrylate acid resin EC ↑↑↑ 西 Antiadherent Surelease R PVAP 国生Coating Method Coating Method Compression- ©Sugar coating ⊕Film cooting coated tablets 门-- ·Advantages ，dvartases ·Blegant final peoduct. 胃 苦安 ·Tablets can be prined fori女tifiction purposes ·Cheap,eadily available装arting幽ters. Simple equipment requiremenes. Exellent protection froer .Disadvuntages ·Enee企abk +Long process time. Traditional mfcture n than asciene ◆High opero depend女ngy. .Significantly increases tabletsie. 1818 Shanghai Jiao Tong University Solvents Ethanol Isopropanol Acetone Water Shanghai Jiao Tong University Aqueous polymeric dispersions Nontoxic Low viscosity High polymer content Productive Shanghai Jiao Tong University Aqueous polymeric dispersions Latexes 胶乳 Pseudolatexes 伪胶乳 Micronized polymeric powder粉末分散物 Shanghai Jiao Tong University Mechanism of film formation Shanghai Jiao Tong University Aqueous polymeric dispersions Polymer Plasticizer Pore material Pigment Antiadherent …… Shanghai Jiao Tong University Aqueous polymeric dispersions Brand Polymer component Eudragit Acrylate acid resin Aquacoat EC Surelease EC Sureteric PVAP Compression￾coated tablets Shanghai Jiao Tong University Coating Method Sugar coating • Advantages • Elegant final product. • Tablets can be printed for identification purposes. • Cheap, readily available starting materials. • Simple equipment requirements. • Excellent protection from environment. • Disadvantages • Long process time. • Traditional manufacture more an art than a science; • High operator dependency. • Significantly increases tablet size. Shanghai Jiao Tong University Coating Method Film coating • Advantages • Quick process, easy to automate. • Negligible increase in tablet size. • Tablets can be identified either by printing or through intagliations. • Minimal effect on drug release. • Enteric coating feasible. • Disadvantages • Finish not as elegant as sugar coating. • Coating process stresses tablet formulation, cores must be robust to resist abrasion and edge chipping during coating