Fudan University Cancer Center Invasion and Cell Motility The first step of metastasis Normal tissue requires proper adhesions with basement membrane and or neighboring cells Cells must undergo changes in their cell-cell and cell-matrix adhesion interactions to dissociate themselves from the tumor Tumor cells display diminished cellular adhesion allowing them to become motile Tumor cells use their migratory and invasive properties in order to burrow through surrounding extracellular stroma and to gain entry into blood vessels and lymphatics Cell motility is a critical component of the invasive phenotype. 复旦大学上海医学院肿瘤学系复旦大学上海医学院肿瘤学系 Fudan University Cancer Center Invasion and Cell Motility • The first step of metastasis. • Normal tissue requires proper adhesions with basement membrane and/or neighboring cells. • Cells must undergo changes in their cell-cell and cell-matrix adhesion interactions to dissociate themselves from the tumor. • Tumor cells display diminished cellular adhesion, allowing them to become motile. • Tumor cells use their migratory and invasive properties in order to burrow through surrounding extracellular stroma and to gain entry into blood vessels and lymphatics. • Cell motility is a critical component of the invasive phenotype